Welcome to the Villeneuve Lab

The Villeneuve Lab is interested in how the brain ages with a specific focus on the factors that modify the association between brain lesions and cognitive performances. Our research is motivated by the fact that more than 25% of older adults are considered cognitively normal despite the presence of beta-amyloid in their brain, a hallmark of Alzheimer’s disease. This fact suggests that other factors interact with beta-amyloid to trigger the expression of cognitive deficits in Alzheimer’s disease. It also suggests that actions can be taken to prevent or postpone the expression of disease-related symptoms. The main focus of The Villeneuve Lab’s research is therefore to examine the factors that protect (or worse) the development of cognitive deficits in age-related neurodegenerative diseases. We use a multi-tier approach that includes molecular PET imaging, MRI imaging, neuropsychological testing, and genetics.

Visit our research page to learn more about our ongoing projects.

 

Recent News

Congratulations to Melissa, Alexa, Julie, Pierre, and Theresa!
29 Mar 2018

Their abstracts got accepted and they will be presenting their work at Villeneuve Lab at both Alzheimer’s Imaging Consortium (AIC) and Alzheimer’s Association International Conference (AAIC) which will take place in Chicago on July 2018.
Melissa“Neuropsychiatric Burden Is Related to Increased Amyloid but Not Tau Deposition in Late-Middle-Aged Cognitively Normal Individuals with a Family History of Alzheimer’s Disease”
Alexa: “Early Increase in Tau-PET Signal Is Associated with Aβ Burden, CSF p-Tau Levels, and Cognition in Cognitively Normal Late-Middle-Aged Adults”
Julie: “Genetic and Environmental Factors Are Differentially Related to Aβ Burden in the Presymptomatic Phase of Autosomal Dominant and Sporadic Alzheimer’s Disease”
Theresa: “Cerebral GABA, resting-state functional connectivity and memory function in Alzheimer’s disease”

A warm welcome to Theresa, our new postdoctoral student!

15 Mar 2018

We would like to give a warm welcome to our new lab member Theresa Köbe. Theresa joined us from Berlin, Germany as a Postdoctoral Student. Her project here focuses on the impact of vascular burden on preclinical Alzheimer’s disease pathology.

You can read more about Theresa, including their previous work and some of their interests, on our people page. 

Villeneuve Lab in Media

12 Mar 2018

The Alzforum weekly newsletter featured an article by Madolyn Bowman Rogers covering Dr. Villeneuve’s paper. You can read the article here.

26 Feb 2018

Dr. Villeneuve and her team had the chance to be interviewed by TVA and Radio Canada on February 26th. The interviews are about Dr. Villeneuve’s recent publication on the link between amyloid accumulation and proximity to parental symptom onset in individuals with a family history of Alzheimer’s disease. You can watch the interview with TVA here and the one with Radio-Canada here. You can also access the press release published by McGill University on this study here.