Welcome to the Villeneuve Lab

The Villeneuve Lab is interested in how the brain ages, with a specific focus on factors that modify the association between brain lesions and cognitive performance. Our research is motivated by the fact that more than 25% of older adults are considered cognitively normal despite the presence of beta-amyloid in their brain, a hallmark of Alzheimer’s disease. This fact suggests that other factors interact with beta-amyloid to trigger cognitive deficits in Alzheimer’s disease. It also suggests that actions can be taken to prevent or postpone disease-related symptoms. The main focus of the Villeneuve Lab’s research is therefore to examine the factors that protect against, or worsen, the development of cognitive deficits in age-related neurodegenerative diseases.

We use a multi-tier approach that includes molecular PET imaging, MRI imaging, neuropsychological testing and genetics, combined with analytic tools such as deep learning, lasso regression and partial least squares regression.

Visit our research page to learn more about our ongoing projects.


Recent News

The Villeneuve Lab welcomes Daniel Bowie
January 2024

We would like to give a warm welcome to Daniel Bowie, who joins the Villeneuve lab as a post-doctoral fellow. Daniel will study how aging and vascular risk factors contribute to Alzheimer’s disease pathology and symptomatology. You can read more about Daniel on our lab members page.


Frédéric St-Onge defends his PhD thesis
January 2024

Congratulations to Frédéric St-Onge on successfully defending his PhD thesis! The Villeneuve lab is grateful to have worked with Fred over the last four and a half years, and wishes him continued success in his career.


Human Amyloid Imaging conference
January 2024

Dr. Sylvia Villeneuve, Alfonso Fajardo-Valdez, Yara Yakoub, Jonathan Gallego Rudolf and Dr. Valentin Ourry attended this year’s Human Amyloid Imaging conference (HAI 2024) in Miami to present some of the lab’s recent work. Sylvia and Alfonso gave podium presentations. Jonathan and Valentin presented posters, and Yara presented two posters. Congratulations to Valentin and Alfonso, who were awarded travel scholarships. Thanks to all for a wonderful conference! [Presentations] [Photos]


New Article from the Villeneuve Lab
November 2023

Valentin Ourry’s article “How do modifiable risk factors affect Alzheimer’s disease pathology or mitigate its effect on clinical symptom expression?” has been published in Biological Psychiatry. This review provides an overview of the pathways and mechanisms by which modifiable risk factors may influence amyloid and tau burden and their effect on cognition in Alzheimer’s disease. [Papers]

Dr. Villeneuve in the media
August 2023

Dr. Sylvia Villeneuve and Dr. Judes Poirier were invited to the TV studios of CBC/Radio-Canada, where they answered questions from the public about Alzheimer’s disease on two episodes of the live call-in show La période de questions. [Media and Press]

New Article from the Villeneuve Lab
August 2023

Frédéric St-Onge’s paper “Functional connectome fingerprinting across the lifespan” has been published in Network Neuroscience. We found that individuals have unique signatures of brain activity that can be identified using functional MRI scans throughout the adult lifespan. [Papers]

More lab news here.