Welcome to the Villeneuve Lab

The Villeneuve Lab is interested in how the brain ages with a specific focus on the factors that modify the association between brain lesions and cognitive performances. Our research is motivated by the fact that more than 25% of older adults are considered cognitively normal despite the presence of beta-amyloid in their brain, a hallmark of Alzheimer’s disease. This fact suggests that other factors interact with beta-amyloid to trigger the expression of cognitive deficits in Alzheimer’s disease. It also suggests that actions can be taken to prevent or postpone the expression of disease-related symptoms. The main focus of The Villeneuve Lab’s research is therefore to examine the factors that protect (or worse) the development of cognitive deficits in age-related neurodegenerative diseases. We use a multi-tier approach that includes molecular PET imaging, MRI imaging, neuropsychological testing, and genetics.

Visit our research page to learn more about our ongoing projects.


Recent News

Villeneuve Lab in Media

12 Mar 2018

The Alzforum weekly newsletter featured an article by Madolyn Bowman Rogers covering Dr. Villeneuve’s paper. You can read the article here.

26 Feb 2018

Dr. Villeneuve and her team had the chance to be interviewed by TVA and Radio Canada on February 26th. The interviews are about Dr. Villeneuve’s recent publication on the link between amyloid accumulation and proximity to parental symptom onset in individuals with a family history of Alzheimer’s disease. You can watch the interview with TVA here and the one with Radio-Canada here. You can also access the press release published by McGill University on this study here.

New Article by Sylvia Villeneuve
26 Feb 2018
A new article by Dr. Villeneuve: “Proximity to parental symptom onset and amyloid burden in sporadic Alzheimer’s disease”, has been published in JAMA Neurology. This study show s that as individuals with a family history of sporadic AD approach the age of their parent at symptom onset, they are more likely to show amyloid burden. This finding was confirmed in three different cohorts and was independent of their biological age.


Human Amyloid Imaging Conference 2018
17-19 Jan 2018
Dr. Villeneuve, along with Julie Gonneaud and Alexa Pichet Binette attended this year’s HAI conference in Miami to present some of their recent work. Julie gave a talk comparing sporadic AD and autosomal dominant AD, and Alexa presented her poster at the conference. [Photos]


New Article by Villeneuve Lab alumnus Sander Verfaillie
14 Dec 2017
A new article by Sander Verfaillie, “Subjective cognitive decline is associated with altered default mode network connectivity in individuals with a family history of Alzheimer’s Disease” published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging feature research on the subjective cognitive decline, brain connectivity pattern and family history of dementia.